|
T11539 |
HCV-IN-29
|
|
HCV Protease
|
|
HCV-IN-29 is a hepatitis C virus (HCV) inhibitor. |
|
T11541 |
HCV-IN-30
|
|
Others
,
HCV Protease
|
|
HCV-IN-30 is an HCV NS5A replication complex inhibitor (IC50s: 901 and 102 nM for genotypes 1a and 1b replicons). |
|
T38237 |
2′-O-Methylcytidine
|
|
Nucleoside Antimetabolite/Analog
,
HCV Protease
|
|
2'-O-Methylcytidine is a nucleoside derivative and an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50= 3.8 μM).1It inhibits HCV replication in a replicon assay (IC50= 21.2 μM).
1.Migliaccio, G.... |
|
T9567 |
Samatasvir
|
ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719 |
HCV Protease
|
|
Samatasvir (ATOLIHZIXHZSBA-BTSKBWHGSA-N) is a pan-genotypic inhibitor of the HCV non-structural protein 5A. |
|
T4686 |
Simeprevir
|
TMC435,TMC-435350,Olysio |
HCV Protease
,
SARS-CoV
|
|
Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM. |
|
T11281L |
FGI-106 tetrahydrochloride
|
|
Virus Protease
,
HCV Protease
,
Influenza Virus
,
HIV Protease
|
|
|
|
TQ0162 |
R-1479
|
4'-Azidocytidine |
HCV Protease
|
|
R-1479 (4'-Azidocytidine) is an RdRp inhibitor with an IC50 value of 1.28 μM for HCV RNA replication in the HCV subgenomic replicon system. |
|
T16088 |
MK-0608
|
|
HCV Protease
|
|
MK-0608 is an orally bioavailable HCV replication inhibitor in vitro(EC50 = 0.3 μM and EC90=1.3 μM in the subgenomic-replicon assay). |
|
T9331 |
Bemnifosbuvir hemisulfate
|
AT-527 |
HCV Protease
,
SARS-CoV
|
|
Bemnifosbuvir hemisulfate (AT-527) is a potent inhibitor of HCV virus replication. |
|
T3489 |
Dasabuvir
|
ABT-333 |
HCV Protease
|
|
Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra... |
|
T1822L |
Clemizole hydrochloride
|
|
HCV Protease
,
Histamine Receptor
|
|
Clemizole hydrochloride is an antagonist for H1 histamine receptor. According to the research, Clemizole hydrochloride can inhibit hepatitis C virus (HCV) replication and NS4B's RNA binding. |
|
T16710 |
Mericitabine
|
R-7128,RG 7128,PSI 6130 diisobutyrate |
HCV Protease
|
|
Mericitabine (R-7128) is a nucleoside HCV NS5B polymerase inhibitor. It acts as an RNA chain terminator and prevents the elongation of RNA transcripts during replication. |
|
T12961 |
Sofosbuvir impurity F
|
Sofosbuvir 3',5'-Bis-(S)-phosphate |
HCV Protease
|
|
Sofosbuvir impurity F (Sofosbuvir 3',5'-Bis-(S)-phosphate) is both a diastereomer of Sofosbuvir and an impurity of Sofosbuvir which is an inhibitor of HCV RNA replication. |
|
T1822 |
Clemizole
|
|
HCV Protease
,
Histamine Receptor
|
|
Clemizole is an H1 histamine receptor antagonist, can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication. |
|
T4121 |
Bicyclol
|
SY801 |
HBV
,
Autophagy
|
|
Bicyclol (SY801)(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic viral hepatitis B and C, and also has a certain level of inhibi... |
|
T19675 |
SM360320
|
CL-087,SM 360320,CL 087,1V136,SM-360320,CL087 |
TLR
|
|
SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for ... |
|
T9249 |
ITMN4077
|
|
Antiviral
|
|
ITMN4077 has antiviral activity against Hepatitis C virus infected in human HuH7 cells assessed as inhibition of HCV subgenomic replicon replication with an EC50 of 2.131μM. |
|
T3226 |
Paritaprevir free base
|
ABT-450,Veruprevir |
HCV Protease
|
|
Paritaprevir free base(ABT-450) is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with potential acti... |
|
T60531 |
2'-C-Methyladenosine
|
|
HCV Protease
|
|
2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication and a ribonucleoside diphosphate reductase inhibitor from Corynebacterium renalis.2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed ... |
|
T12962 |
Sofosbuvir impurity G
|
|
HCV Protease
|
|
Sofosbuvir impurity G is a diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity. |
|
T73253 |
EIDD-2749
|
4'-Fluorouridine,4'-FlU ; 4'-Fluorouridine,4'-FlU |
|
|
EIDD-2749 (4'-Fluorouridine), an orally active RdRp inhibitor, effectively inhibits the replication of RSV and SARS-CoV-2. It also demonstrates activity against HCV and lymphocytic choriomeningitis virus (LCMV), highligh... |
|
T19486 |
Nucleoside-Analog-2
|
|
Others
|
|
Nucleoside-Analog-2 is a 4'-Azidocytidine analogue, used to against Hepatitis C virus (HCV) replication. |
|
T14289 |
Anguizole
|
|
Others
|
|
Anguizole, a small molecule, effectively inhibits Hepatitis C Virus (HCV) replication by modifying the subcellular distribution of NS4B. It demonstrates its potency with an IC50 value, highlighting its specific target ac... |
|
T27732 |
KIN1400
|
|
|
|
KIN1400, a novel IRF3 activator, triggers IRF3-dependent innate immune antiviral genes and IFNbeta307 expression, suppresses WNV, DV infection, and HCV replication. |
|
T16774 |
RO-9187
|
|
HCV Protease
|
|
RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM). |
|
T12966 |
Sofosbuvir impurity K
|
|
HCV Protease
|
|
Sofosbuvir impurity K is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity. |
|
T12969 |
Sofosbuvir impurity N
|
|
HCV Protease
|
|
Sofosbuvir impurity N is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity. |
|
T12964 |
Sofosbuvir impurity I
|
|
HCV Protease
|
|
Sofosbuvir impurity I is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity. |
|
T12955 |
Sofosbuvir D6
|
PSI-7977 D6,GS-7977 D6 |
Others
|
|
Sofosbuvir D6 is the deuterium labeled Sofosbuvir. Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. |
|
T12954 |
Sofosbuvir 13CD3
|
GS-7977 13CD3,PSI-7977 13CD3 |
Others
|
|
Sofosbuvir 13CD3 is the deuterium labeled Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay, with potent anti-hepatitis C virus (HCV) activity. |
|
T14095 |
ACH-806
|
GS9132 |
HCV Protease
|
|
|
|
T12968 |
Sofosbuvir impurity M
|
|
HCV Protease
|
|
Sofosbuvir impurity M is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity. |
|
T12965 |
Sofosbuvir impurity J
|
|
HCV Protease
|
|
Sofosbuvir impurity J is an diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity. |
|
T12958 |
Sofosbuvir impurity C
|
|
Others
|
|
Sofosbuvir impurity C is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity. |
|
T12959 |
Sofosbuvir impurity D
|
|
Others
|
|
Sofosbuvir impurity D is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity. |
|
T79626 |
HCV-IN-44
|
|
|
|
HCV-IN-44 (compound 28) is an inhibitor of the HCV NS5B protein, efficacious in suppressing HCV virus replication and useful for researching HCV infection [1]. |
|
T81694 |
NCI-B16
|
|
|
|
NCI-B16 is a small-molecule RNA binder that inhibits HCV (hepatitis C virus) replication [1]. |
|
T71006 |
BI-1388
|
|
|
|
BI-1388 is a highly potent inhibitor of HCV NS3 protease activity, inhibiting viral replication for various HCV genotypes and for resistant mutants D168V and R155K. |
|
T16715 |
Furaprofen
|
R803 |
Others
|
|
|
|
T79625 |
HCV-IN-43
|
|
|
|
HCV-IN-43 (compound 2), an HCV NS5B protein inhibitor, efficiently inhibits HCV virus replication and is utilized in the study of HCV infection [1]. |
|
T69935 |
L0909
|
|
|
|
L0909 is an orally available inhibitors of Hepatitis C virus with a novel mechanism of action (EC50 = 0.022 μM, SI > 600). L0909 could block HCV replication by acting on the HCV entry stage. The high sensitivity to clini... |
|
T39347 |
RG-101
|
|
|
|
RG-101 is a hepatocyte-targeted N-acetylgalactosamine conjugated oligonucleotide that functions as an antagonist for miR-122, an essential host factor in the replication of the hepatitis C virus (HCV). |
|
T33432 |
MK-3281
|
MK 3281,MK3281 |
|
|
MK-3281 is a potent, orally bioavailable hepatitis C virus NS5B polymerase finger-loop inhibitor. It is also an inhibitor of attractive molecular properties with good potency in HCV subgenomic replication trials and suit... |
|
T12960 |
Sofosbuvir impurity E
|
|
Others
|
|
Sofosbuvir impurity E is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity. |
|
T12957 |
Sofosbuvir impurity B
|
|
Others
|
|
Sofosbuvir impurity B is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay, with potent anti-hepatitis C virus (HCV) activity. |
|
T12963 |
Sofosbuvir impurity H
|
|
HCV Protease
|
|
Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is a diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis ... |
|
T74625 |
HCV-IN-41
|
|
|
|
HCV-IN-41 (compound 4), a potent inhibitor of the hepatitis C virus (HCV), demonstrates exceptional inhibitory effectiveness across different genotypes, with EC 50 values of 0.006762 nM for genotype 1b, 5.183 nM for 2a, ... |
|
T70760 |
NVP018
|
|
|
|
NVP018, also known as BC 556, is a potent inhibitor of hepatitis B virus, hepatitis C virus (HCV), and HIV-1 replication, shows minimal inhibition of major drug transporters, and has a high barrier to generation of both... |
|
T71085 |
BMS-824
|
|
|
|
BMS-824 is a potent NS5A inhibitor. The 50% inhibition of HCV replicon replication for BMS-824 was approximately 5 nM, with a therapeutic index of >10,000. BMS-824 showed good specificity for HCV, as it was not active... |
|
T14555 |
BI-1230
|
|
HCV Protease
|
|
BI-1230 is a potent inhibitor of HCV NS3 protease, exhibiting efficacy in the low nanomolar range, and notably suppresses viral replication. This compound demonstrates high selectivity, distinguishing effectively between... |
